Challenge tests are types of tests that measure if your lung function changes after you breathe in specific chemicals. A challenge study with Mannitol may be done to see if you have exercise-induced asthma or how well your asthma medicine is working.
If you have asthma, your airways will tighten. During the MCT, you will inhale a very gradual increasing dosage of Mannitol.
If your breathing does not change with the first dosage, you will be asked to inhale progressively a larger dosage of Mannitol. If your airways tighten at any point, you will be given an inhaled bronchodilator medicine that will re-open your airways.
Often, the person administering the test will know that your airways are tightening before you do because of the breathing test (spirometry) you will be asked to perform before and after each step of the test.
There are several reasons you may not be able to undergo the MCT. You should not have the test for the following reasons:
When in doubt about whether you should have this test, ask your health care provider, and discuss your concerns with your doctor.
Stop the drugs before
Quick acting bronchodilators such as:
· Albuterol (ProventiL Ventolin, ProAir)
· Salbutamol, Etutalin
· Fenoterol (berotec )
· Terbutaline (bricanyl)
Cromolyn sodium (Intal)
Antihistamines such as:
· Cetirizine (zyrtec), Levocetirizine (XazaL)
· Fexofenadine (Fexon, Telfas) or Loratadine (clarityne), Desloratadine (Aerius, Azomyr)
· Ebastine (EbasteL), Bilastine (8ilaxten)
· Dexchlorpheniramine, Others
Leukotriene modifiers such as:
Montelukast (Singular) or Zillirlukast (Accolate)
Ipratropium bromide (Altrovent) or ipratropium /albuterol (combivent)
Combination products such as:
Budesonide/Formoterol (Symbicort) or fiuticasone/Salmeterol (Advair)/Serofio/ Seretide/Relvar/Foster/Flutiform
· Long-acting bronchodilators such as Formoterol (Foradil), Sameterol (Serevent) or tiotropium (Spiriva)
· Theophylline medicines (TheoDur, Theolair, Theo24)